Usi terapeutici della Cannabis
di Marcello Pamio
Non dovevo occuparmene più!
Dopo aver scritto Cannabis connection, mi ero promesso di regalare alla pianta più boicottata dell’umanità un meritato e doveroso riposo. Invece…parlando con diverse persone ho have seen that it is still entrenched misinformation about hemp. A medical misinformation that has forced me to take up the issue once and for all and deal with the perhaps most important of the plant: the therapeutic.
In this regard there is a Pharaonic documents: books, articles, ancient herbals, research and scientific publications, volunteer experiences, etc.. All evidence in favor of cannabis in treating diseases ranging from musculoskeletal pain, glaucoma, from anorexia and depression in epilepsy as a dreadful disease and multiple sclerosis, not to mention the valuable help in relieving the side effects of chemotherapy in cancer, such as nausea and vomiting, and debilitating in the states of the Immune Deficiency Syndrome (AIDS).
The results are so exciting now controlled medical trials have begun in the United States, Germany, Spain, England, Belgium, Israel, Holland and Canada. Even in the latter country, the Medical Association that brings together all the 52 000 doctors would remove from the Canadian Criminal Code the personal use of cannabis and replace it with a simple fine [1]. What to say about the latest study on the abuse of drugs by a British government committee whose conclusion is nothing short of amazing, "Spinel gives less addictive cigarettes and alcohol [2]. Not only that, the group of experts commissioned by British Home Secretary to weigh the pros and cons of an easing of the law on illicit drugs, claims that cannabis may actually do good for your health: cardiovascular action - the report says - is similar to the effects of exercise. "
But what's going on? One of the oldest trees are the first to ban making it illegal for decades - compared to a drug toxic and dangerous to health - and then jump to the headlines currently experiencing a period of quasi-religious redemption. A redemption
hampered by few and hailed by many because of the many other applications practices by the Guinness Book of World Records. In fact, from hemp as well as medicines that work, and that's enough, you can get: indestructible paper, plastic type material, dyes, solvents, highly resistant fabrics, cordage, and more. For this reason, most likely, was the subject of a boycott by the biggest ever in the history known to us. A fitocospirazione from science fiction, if you have not read it yet I suggest you do so as soon as possible (Cannabis connection)
This recent recognition is the awareness of a past mistake of Prohibition free - even if it has nothing to free - or compulsory rehabilitation because of an increasing number of users and evidence of its effectiveness, at least in medical terms? What is certain is that today those who benefits from all this, but very few people authorized by their governments to smoke the "plan", chemical and pharmaceutical corporations are taking advantage of the situation are marketing products of synthesis, called analogues, which emulate the principle active ingredient in cannabis: THC. A competition which we will see below has some minor inconvenience.
But before we look at the physiological level these cannabinoids act as "guilty" of the exceptional therapeutic results.
THC, as we have said is the active ingredient of cannabis, namely that acts directly on the body. Per essere più precisi interagisce con un sistema detto cannabinoide[3] normalmente presente nel corpo umano, e produce i suoi effetti agendo sui recettori del sistema. I recettori sono delle proteine molto speciali che si trovano sulle superfici di determinate cellule. La droga, in soldoni, forma una specie di ponte, un legame con queste proteine e per così dire attiva delle funzioni cellulari interne molto precise. Sono stati identificati due tipi di recettore: il CB1 e il CB2.
I CB1 sono presenti sui neurociti encefalici e spinali come in certi tessuti periferici; i CB2 si trovano principalmente sulle cellule del sistema immunitario ma non nel cervello[4].
Questo è molto interessante: abbiamo recettori della cannabis sul cervello e even in the immune system [5].
To have the record it is also proper to emphasize that there is not only THC, this is undoubtedly the most famous and the most present in the plant, but there are more than 60 different cannabinoids from each other. At present not much is known about the properties of these cannabinoids that if you do not seem to be devoid of psychoactive effects and / or psychotropic drugs on the brain. Thus the hypothesis that also positively influence the therapeutic effects of cannabis on human behavior without interfering not be ruled out.
Ultimately these cannabinoids interact with lots of natural body functions and can among other things block the release of glutamic acid, the major neurotransmitter implicated in the pathogenesis of stroke [6]; release dopamine, another important neurotransmitter linked to the ability to control movements, and many other more subtle aspects that are at an advanced stage of study. About Study: I \u200b\u200bfirst mentioned the several trials that are being made all over the world. Well. The experiments for the uninitiated are always expensive, and no research institution would dream of spending money without the mathematical certainty of a considerable advantage. One advantage is that often materializes in a drug or therapy. In the case of cannabis have, for the moment, two synthetic self-interest: Dronabinol and nabilone. There could be others, such as Levonantradolo, the HU-210, SR141716A, etc.. but for the moment are available only for experimental uses. For the moment though. ... Tomorrow is another day.
dronabinol, whose commercial name is Marinol ® is manufactured by Unimed Pharmaceuticals Inc., a company of Solvay Pharmaceuticals Corporation. Also called nabilone Cesamet ® is manufactured in England by Cambridge selfcare Diagnostics Ltd on behalf of Eli Lilly Corporation, to be clear that the Prozac ® [7].
Of course this was a must comb through the package inserts of these drugs. What do you think we found? We are always on the usual: svariati effetti collaterali! Fin qui nulla di strano, visto che non esistono medicinali di sintesi privi di controindicazioni. Però se vi dicessi che le reazioni avverse sono le stesse curate però dalla pianta naturale, come anoressia, depressione, astenia[8], la cosa non assume una aspetto tragicomico? Se uso per esempio la “cannabis sintesis” per aiutare un’astenia potrei vedere insorgere una depressione accompagnata pure da vertigini. Oppure, che ne so, per alleviare nausea e vomito provoco palpitazioni e/o ansietà. Interessante vero? Si cura da una parte e si pagano le conseguenze dall’altra! L’onnipresente rovescio della medaglia. Sicuramente il dritto sarà un basso costo di vendita al pubblico, right? Wrong. About twenty capsules Cesamet ® for example, cost about 102 pounds [9]! And Marinol is more expensive [10]. Do you understand? A single tablet, to understand, it costs more than 15 thousand pounds of old! Rather than a straight, I think another wrong! The problem is that no one is playing tennis, here we are dealing with life and health, already precarious, with many suffering people.
At present, therefore, on the one hand we have a plant that could be free to illegal grow at almost every latitude without pesticides and with a time of rapid maturation of a few months, other synthetic products that are expensive, require different years of study and have minor inconveniences should not be underestimated.
What to do at this point? Legalize the banned crop par excellence, cataloged since the '60s in the field of "drug with no therapeutic effect [11], or continue not to see the results in treatment focusing exclusively in the synthetic chemistry? What do you think will choose the democratic governments of the European Union addressed perhaps by powerful transnational corporations in the chemical and pharmaceutical industry? I have a vague idea I have, I do not know you ... No one
certainly would want a healthy society in which people pretend to be sick inventing fictitious diseases or even worse, falsifying tests to be prescribed by your doctor sigarettina a stuffed, or worse still see patients who suffer debilitating diseases really heavy that can not use products derived from the cannabis if not hospital patients, as is happening today in our country. The pharmacy of the Policlinico Umberto I, for example, but this applies to all hospitals, may administer the drug derived from THC only after admission [12]. This is not a bureaucratic nonsense Italian? A person can easily follow the treatment in the comfort of home, perhaps with the closeness of loved ones, is obliged to enter into the aseptic and cold of a hospital.
We hope then that the recent steps Drawing of Law which would introduce the therapeutic use of cannabis. This at least allows you to find the synthetic pesticides directly to the pharmacy, subject of course a recipe for your health care provider.
In anticipation of this design we conclude with a comparison from the practical point of view between the pill and pharmacological and synthetic plurimillennaria evergreen plant.
I shall digress a duty because the influencing factors in the case of natural cannabis is enormous and moods of the person, how much and how the smoke is drawn, how much cannabis cigarette contains, as THC is present in the plant, the type of plant, etc..
close the brackets and get ready to enter the field.
The smoke of a cannabis cigarette released in the circulation over 30% of the total THC, while orally, the pill, is 2 or 3 times lower than that after being absorbed through the gut is metabolized by the liver before reaching the great circle [13].
One to zero for cannabis and ball in the center. To be honest there would be a punishment for chemistry if we consider the rectal suppositories bypassing the liver which allow a greater absorption of THC into the circulation.
Once in the bloodstream THC is distributed throughout the body mainly in adipose tissue because it is soluble only in the fat melts. This intrinsic property of cannabis is a big limit for the delivery of prepared cannabis, as well as slow down their absorption in the intestine [14]. Two
to zero and again the ball in the center.
Regarding the pharmacological effects of cannabis documented so far are related to the respiratory tract. A study of the Western Journal of Medicine on 9 June 1993 [15] states that anyone who smokes cannabis is likely to respiratory diseases for 19% more than those who do not smoke, and no dependency and / or physical addiction has been demonstrated but a sporadic psychological dependence in some people. The other we have the side effects of Marinol ® and Cesamet ® before. We
a point to chemical synthesis because not everybody would willing to use the plant through the cigarette. However, if we consider that the sixty natural cannabinoid content in hemp, the drug products currently on the market are based almost exclusively in the tetrahydrocannabinol (THC), the one with psychotropic effects, neglecting the others fifty-nine no activity on the brain, it is reasonable to think that the At present, the plant could be at least sixty times more complete than any product out of a research laboratory. Finally, by calculating the respective costs quite unparalleled the end result is four to one for the cannabis! You understand that this is a race if it did really surreal because the arbrito, represented by the drug lobby, whistling at least two or three penalties for expelling maybe some cannabinoid chemistry for "intervention" too determined. We can only hope so in an invasion of the field once and for all put an end to this senseless and counterproductive rivalries. A "peaceful invasion" by a growing awareness that gives, indeed re-dia, the main role for the sick to be living and sanctify once and for all one of the most important rights: that of the free choice of therapy. This choice belongs exclusively to individuals and healthcare organizations, much less to corporations, because once you are on the road ... therapeutic us suffer the consequences and / or enjoy the benefits. No one else!
Marcello Pamio