ScienceDaily (Mar. 3, 2011) - Blood Group Incompatibility Between Henry VIII and His Wives Could Have driven the Tudor king's reproductive Woese, and a genetic condition related to His Suspected blood group Could Also explain Henry's dramatic mid-life transformation into a physically and mentally -impaired tyrant who Executed Of His two wives. ScienceDaily (Mar. 3, 2011) - Blood group incompatibility between Henry VIII and his wives would have compelled the Tudor king reproductive trouble ', and a genetic condition related to his suspected blood group may also explain the dramatic mid-life transformation Henry tyrant in a physically and mentally impaired who performed two of his wives.
Research Conducted Catrina Whitley bioarchaeologist by Banks while she Was a graduate student at SMU (Southern Methodist University) and Kyra Anthropologist Kramer shows the Numerous miscarriages That Suffered by Henry's wives Could Be Explained if the king's blood Carried the Kell antigen. Research conducted by bioarchaeologist Catrina Whitley Banks, while a student at SMU (Southern Methodist University) and anthropologist Kyra Kramer, shows that the abortions suffered by many wives of Henry could be explained if the blood of the king made the Kell antigen. A Kell negative woman who has multiple pregnancies with a Kell positive man can produce a healthy, Kell positive child in a first pregnancy; But she Produces Antibodies During the first pregnancy That will cross the placenta attack and a Kell positive fetus in subsequent pregnancies. Kell negative woman has multiple pregnancies with a Kell positive man can produce a healthy, positive Kell child in a first pregnancy, but the antibodies produced during pregnancy that first crosses the placenta and attack a Kell positive fetus in subsequent pregnancies .
As published in The Historical Journal (Cambridge University Press), the pattern of Kell Blood Group Incompatibility is consistent with the pregnancies of Henry's first two wives, Katherine of Aragon and Anne Boleyn. As published in The Historical Journal (Cambridge University Press), the model of Kell blood group incompatibility is consistent with the pregnancies of Henry first two wives, Caterina d'Aragona e Anna Bolena. If Henry also suffered from McLeod syndrome, a genetic disorder specific to the Kell blood group, it would finally provide an explanation for his shift in both physical form and personality from a strong, athletic, generous individual in his first 40 years to the monstrous paranoiac he would become, virtually immobilized by massive weight gain and leg ailments. Se Henry ha sofferto della sindrome di McLeod, una malattia genetica specifica per il gruppo sanguigno Kell, sarebbe finalmente una spiegazione per il suo cambiamento sia nella forma fisica e la personalità di un forte, atletico, singoli generosi nei suoi primi 40 anni per il paranoico mostruoso sarebbe diventato, praticamente immobilizzato dal massiccio aumento di peso e leg issues.
"It is our assertion That We Have Identified the underlying causal medical condition Henry's reproductive problems and psychological deterioration," write Whitley and Kramer. "It 's our claim that we have identified the causal condition practitioner Henry reproductive problems and psychological degradation," writes Kramer and Whitley.
Henry married six women, two of Whom he famously Executed, and broke England's ties with the Catholic Church - all in pursuit of a marital union That Would produces bad heir. Henry married six women, two of whom he famously executed, and England broke ties with the Catholic Church - all in search of a marital union that would produce a male heir. Historians Have long debated theories of illness and injury That Might explain the physical deterioration and frightening, tyrannical behavior That he Began to display after His 40th birthday. Historians have long debated the theories of illness and injury that might explain the physical deterioration and scary, tyrannical behavior that began to appear after his 40th birthday. Less attention has Been given to the wives Of His Unsuccessful pregnancies in an age of primitive medical care and poor nutrition and hygiene, and authors and Kramer Whitley Argue Against the persistent theory syphilis That May Have Been a factor. Less attention has been given to unsuccessful pregnancies of his wives at a time when primary care Medical and poor nutrition and hygiene, and the authors Whitley and Kramer argue against the persistent theory that syphilis may have been a factor. Kell
A positive father is frequently the cause behind the Inability to bear Of His partner in healthy infants after the first negative pregnancy Kell, Which Is Precisely the authors note the circumstance experienced with multiple pregnancies by women who HAD Henry. A father Kell positive is often the cause behind the failure of its partners to bring a healthy baby, after the first pregnancy Kell negative, the authors note that it is precisely the circumstance experienced by women who have had multiple pregnancies by Henry. The Majority of individuals Within The Kell blood group are Kell negative, so it is the rare Kell positive father that creates reproductive problems. La maggior parte degli individui del gruppo sanguigno Kell sono Kell negativi, per cui è il padre raro Kell positivo che crea problemi riproduttivi.
Further supporting the Kell theory, descriptions of Henry in mid-to-late life indicate he suffered many of the physical and cognitive symptoms associated with McLeod syndrome -- a medical condition that can occur in members of the Kell positive blood group. Inoltre sostiene la teoria Kell, descrizioni di Henry in vita medio-tardo indicare che patì molti dei sintomi fisici e cognitivi associati con la sindrome di McLeod - una condizione medica che può verificarsi nei membri del gruppo sanguigno positivo Kell.
By middle age, the King Suffered from chronic leg ulcers, fueling longstanding historical speculation That he Suffered from type II diabetes. By middle age, the king was suffering from chronic ulcers, fueling speculation that long-standing historical suffering from diabetes type II. The ulcers Also Could Have Been Caused by osteomyelitis, a chronic bone infection That Would Have Made walking Extremely painful. Ulcers may also have been caused by osteomyelitis, a chronic infection of the bones that would have to walk very painful. In the last years of His life, Henry's mobility deteriorated to the point HAD That He Was Carried about in a chair with poles. In the last years of his life, Henry's mobility had deteriorated to the point that he was carried on a chair with poles. That immobility is consistent with a Known McLeod syndrome patient case in Which Began to notice a weakness in His right leg When He Was 37, and atrophy in Both His legs by age 47, the report notes. That the property is consistent with a known case of McLeod syndrome in which a patient began to notice weakness in his right leg when he was 37, and atrophy in both legs at the age of 47 years, the report notes.
Whitley and the Tudor king Kramer Argue That Could Have Been suffering from Medical Conditions Such as These in combination with McLeod syndrome, aggravated by His obesity. Whitley and Kramer argue that the Tudor king could be suffering from medical conditions such as This, combined with the McLeod syndrome, aggravated by his obesity. Records do not set Henry Displayed Whether other physical signs of McLeod syndrome, Such as sustained muscle contractions (tics, Cramps or spasms) or an Increase in abnormal muscle activity Such as twitching or hyperactivity. Records do not indicate whether Henry displayed other signs of physical McLeod syndrome, such as sustained muscle contractions (tics, spasms or cramps) or an abnormal increase in muscle activity such as twitching or hyperactivity. But the dramatic changes in His personality Provide Stronger Evidence That HAD Henry McLeod syndrome, the authors point out: His mental and emotional instability Increased in the dozen years before death to an extent That Have Some His behavior labeled psychotic. But dramatic changes in his personality provide strong evidence that Henry had the McLeod syndrome, the authors point out, his mental and emotional instability increased in the years before the death of tens to the point that some have labeled her psychotic behavior.
McLeod syndrome resembles Huntington's disease, muscle coordination and Causes Which Affects cognitive disorder. McLeod syndrome resembling Huntington's disease, which affects muscle coordination and causes cognitive problems. Usually McLeod Symptoms begin to Develop When an individual is between 30 and 40 years old, Often resulting in damage to the heart muscle, muscular disease, psychiatric and motor nerve abnormality damage. McLeod Symptoms usually start to develop when an individual is between 30 and 40 years, often resulting in damage to the heart muscle, muscle diseases, psychiatric disorders and damage to motor nerves. Henry VIII experienced most, if not all, of These Symptoms, the authors found. Henry VIII tried most, if not all, of these symptoms, the authors found.
Fetal Mortality, Infertility Is Not the Kell Legacy fetal mortality, infertility is not the Legacy Kell
Henry Nearly Was 18 When He married 23-year-old Catherine of Aragon. Henry was almost 18 when he married 23 years, Catherine of Aragon. Their first daughter, a girl, Was stillborn. Their first figlia, una ragazza, era nato morto. Their second child, a boy, lived only 52 days. Il loro secondo figlio, un ragazzo, ha vissuto solo 52 giorni. Four other confirmed pregnancies followed during the marriage but three of the offspring were either stillborn or died shortly after birth. Quattro altre gravidanze confermato seguita durante il matrimonio, ma tre dei figli erano nati morti o morti subito dopo la nascita. Their only surviving child was Mary, who would eventually be crowned the fourth Monarch in the Tudor dynasty. Il loro unico figlio superstite era Maria, che alla fine, sarebbe incoronato il quarto monarca della dinastia Tudor.
The precise number of miscarriages endured by Henry's reproductive partners is difficult to determine, especially Various When mistresses are factored in, But the king's partners Had A total of at least 11 and possibly 13 or more pregnancies. The exact number of abortions experienced by reproductive partner of Henry is difficult to determine, especially when the various lovers are caught in, but the partners of the king had a total of at least 11 and perhaps 13 or more pregnancies. Only four of the eleven Known pregnancies SURVIVED infancy. Only four of the eleven known pregnancies survived infancy. Whitley and Kramer call the high rate of spontaneous late-term abortion, Stillbirth, or rapid neonatal death Suffered by Henry's first two queens "an atypical reproductive pattern" Because, even in an age of high child mortality, most women Carried Their pregnancies to term , Usually infants and Their lived long enough to be christened. Whitley and Kramer called the high rate of spontaneous late-term abortion, stillbirth or neonatal death suffered by Henry rapid first two queens, a reproductive pattern atypical "because even in an era of high infant mortality, most women carried their pregnancies to term, and their children often lived long enough to be baptized.
The authors explain That if a father impregnates a positive Kell Kell negative mother, Each pregnancy has a 50-50 chance of Being Kell positive. The authors explain that if a father impregnates a positive Kell Kell negative mother, every pregnancy has a 50-50 to be Kell positive. The first pregnancy to term and Carries Typically Produces a healthy infant, even if the infant is Kell positive and the mother is Kell negative. The first pregnancy usually leads to term and produce a healthy baby, even if the child is Kell positive and the mother is Kell negative. But the mother's subsequent Kell positive pregnancies are at risk Because the mother's positive Kell Antibodies will attack the fetus as a foreign body. But the mother Kell positive pregnancies are at risk because the mother's antibodies attack the Kell positive fetus as a foreign body. Any baby That is Kell negative Will Not Be Attacked by the mother's Antibodies and will carry to term if healthy Com. Every baby that is not attacked by Kell negative antibodies from the mother and complete otherwise healthy.
"although the fact That Henry and Katherine of Aragon's firstborn did not survive is Somewhat atypical, it is possible That Affect Some cases of Kell sensitization even the first pregnancy," the report notes. "Despite the fact that Henry and Catherine of Aragon, first-born not to survive is a bit 'unusual, it is possible that some cases of Kell sensitization also affect the first pregnancy," the report noted. The survival of Mary, the fifth pregnancy for Katherine of Aragon, fits the scenario if Mary Kell Kell inherited the recessive gene from Henry, resulting in a healthy infant. The survival of Mary, the fifth pregnancy to Catherine of Aragon Kell is part of the scenario if Mary has inherited the recessive gene from Henry Kell, resulting in a healthy child. Anne Boleyn's pregnancies Were A textbook example of Kell alloimmunization with a healthy first child and subsequent late-term miscarriages. Anna Bolena pregnancies were a textbook example of a healthy child with Kell alloimmunization prior to and subsequent abortions late term. Jane Seymour HAD only one child before her death, But Also That healthy firstborn is consistent with a Kell positive father. Jane Seymour had a son just before his death, but that first-born healthy is also consistent with a father Kell positive.
Several of Henry's evil relatives Followed the Kell positive maternal reproductive patterns. Many of the male relatives di Enrico materno seguito il positivo Kell modello riproduttivo.
"We have traced the possible transmission of the Kell positive gene from Jacquetta of Luxembourg, the king's maternal great-grandmother," the report explains. "Abbiamo tracciato la possibile trasmissione del gene Kell positivo da Jacquetta di Lussemburgo, del re materna bisnonna", spiega il rapporto. "The pattern of reproductive failure among Jacquetta's male descendants, while the females were generally reproductively successful, suggests the genetic presence of the Kell phenotype within the family." "Il modello di problemi riproduttivi tra i discendenti maschi Jacquetta, mentre le femmine erano in genere di successo riproduttivo, suggerisce la presenza genetico del fenotipo Kell all'interno della famiglia."
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